• Kristian Nzogang Fomo ,Natarajan Perumal,Caroline Manicam,Norbert Pfeiffer and Franz H. Neuroretinal Cell Culture Model as a Tool for the Development of New Therapeutic Approaches for Oxidative Stress-Induced Ocular Diseases, with a Focus on Glaucoma.  Grus; Cells 202413(9), 775;
    • Sichang Qu Hao Lin Norbert Pfeiffer Franz H Grus Age-Related Macular Degeneration and Mitochondria-Associated Autoantibodies: A Review of the Specific Pathogenesis and Therapeutic Strategies.  Int. J. Mol. Sci.; 2024 Jan 28;25(3):1624. doi: 10.3390/ijms25031624. Age-Related Macular Degeneration and Mitochondria-Associated Autoantibodies: A Review of the Specific Pathogenesis and Therapeutic Strategies (
    • Natarajan Perumal, Hajime Yurugi, Katrin Dahm, Krishnaraj Rajalingam, Franz H. Grus, Norbert Pfeiffer, Caroline Manicam Proteome Landscape and Interactome of Voltage-Gated Potassium Channel 1.6 (Kv1.6) of the Murine Ophthalmic Artery and Neuroretina.
      International J of Biological Macromolecules ; 2024; 257
    • Martin Schicht, Jessica Farger, Saskia Wedel, Marco Sisignano, Klaus Scholich, Gerd Geisslinger, Natarajan Perumal, Franz H. Grus, Swati Singh, Afsun Sahin, Friedrich Paulsen, Elke Lütjen-Drecoll,
      Ocular surface changes in mice with streptozotocin-induced diabetes and diabetic polyneuropathy,
      The Ocular Surface, Volume 31, 2024, Pages 43-55, ISSN 1542-0124,



    • Pham TNM, Perumal N, Manicam C, Basoglu M, Eimer S, Fuhrmann DC, Pietrzik CU, Clement AM, Körschgen H, Schepers J, Behl C (2023).  Adaptive responses of neuronal cells to chronic endoplasmic reticulum (ER) stress. Redox Biol. doi: 10.1016/j.redox.2023.102943. PMID: 37883843; PMCID: PMC10618786.

    • Chronopoulos P, Manicam C, Zadeh JK, Laspas P, Unkrig JC, Göbel ML, Musayeva A, Pfeiffer N, Oelze M, Daiber A, Li H, Xia N, Gericke A (2023). Effects of Resveratrol on Vascular Function in Retinal Ischemia-Reperfusion Injury. Antioxidants (Basel). 1;12(4):853. doi: 10.3390/antiox12040853

    • Korb CA, Beck S, Wolters D, Lorenz K, Pfeiffer N, Grus FH (2023); Serum Autoantibodies in Patients with Dry and Wet Age-Related Macular Degeneration. J. Clin. Med. 2023, 12(4), 1590;

    • Korb CA, Lackner KJ, Wolters D, Schuster AK, Nickels S, Beutgen VM, Munzel T, Wild PS, Beutel ME, Schmidtmann I, Pfeiffer N, Grus FH (2023)Association of autoantibody levels with different stages of age-related macular degeneration (AMD): Results from the population-based Gutenberg Health Study (GHS).Graefe's archive for clinical and experimental ophthalmology

    • Schmelter C., Brueck A., Perumal N., Qu S., Pfeiffer N., Grus F.H.; Lectin-Based Affinity Enrichment and Characterization of N-Glycoproteins from Human Tear Film by Mass Spectrometry;  Molecules 2023, 28(2), 648;

    • Schmelter CarstenFomo Kristian NzogangBrueck AlinaPerumal NatarajanMarkowitsch Sascha D. D., Govind Gokul, Speck Thomas, Pfeiffer NorbertGrus Franz H. H. Glaucoma-Associated CDR1 Peptide Promotes RGC Survival in Retinal Explants through Molecular Interaction with Acidic Leucine Rich Nuclear Phosphoprotein 32A (ANP32A)   (2023) BIOMOLECULES. 2023; 13(7). Article

    • Buonfiglio, F.; Xia, N.; Yüksel, C.; Manicam, C.; Jiang, S.; Zadeh, J.K.; Musayeva, A.; Elksne, E.; Pfeiffer, N.; Patzak, A.; Li, H.; Gericke, A (2023). Effects of Chronic Apolipoprotein E Deficiency on Mouse Ophthalmic Artery Reactivity. Diseases. Preprints 2023, 2023081630.


    • Perumal N, Herfurth A, Pfeiffer N, Manicam C. (2022). Short-Term Omega-3 Supplementation Modulates Novel Neurovascular and Fatty Acid Metabolic Proteome Changes in the Retina and Ophthalmic Artery of Mice with Targeted Cyp2c44 Gene Deletion.Cells. 2022; 11(21):3494.

    • Kristian N. Fomo, Carsten Schmelter, Joshua Atta, Vanessa M. Beutgen, Rebecca Schwarz, Natarajan Perumal, Gokul Govind, Thomas Speck, Norbert Pfeiffer and Franz H. Grus Synthetic antibody-derived immunopeptide provides neuroprotection in glaucoma through molecular interaction with retinal protein Histone H3.1Front. Med., Sec. Ophthalmology , doi: 10.3389/fmed.2022.993351 

    • Tonner H, Hunn S, Auler N, Schmelter C, Beutgen VM, von Pein HD, Pfeiffer N, Grus FH (2022)  A Monoclonal Anti-HMGB1 Antibody Attenuates Neurodegeneration in an Experimental Animal Model of Glaucoma. Int J Mol Sci 23.

    • Fomo KN, Schmelter C, Pfeiffer N, Grus FH.   Tear Film-specific Biomarkers in Glaucoma Patients. Klin Monbl Augenheilkd. 2022 Feb;239(2):165-168. doi: 10.1055/a-1749-6972. Epub 2022 Feb 24. PMID: 35211938 English, German.

    • Hetsch F, Wang D, Chen X, Zhang J, Aslam M, Kegel M, Tonner H, Grus F, von Engelhardt J (2022);  CKAMP44 controls synaptic function and strength of relay neurons during early development of the dorsal lateral geniculate nucleus. J Physiol 600:3549-3565.



    • Auler N, Tonner H, Pfeiffer N, Grus FH (2021) Antibody and Protein Profiles in Glaucoma: Screening of Biomarkers and Identification of Signaling Pathways. Biology (Basel) 10. Antibody and Protein Profiles in Glaucoma: Screening of Biomarkers and Identification of Signaling Pathways (
    • Schmelter C, Fomo KN, Perumal N, Pfeiffer N, Grus FH (2021) Regulation of the HTRA2 Protease Activity by an Inhibitory Antibody-Derived Peptide Ligand and the Influence on HTRA2-Specific Protein Interaction Networks in Retinal Tissues. Biomedicines 9.

    • Beutgen VM, Schmelter C, Pfeiffer N, Grus FH (2021) Contribution of the Commensal Microflora to the Immunological Homeostasis and the Importance of Immune-Related Drug Development for Clinical Applications. International journal of molecular sciences 22.

    • Beutgen VM, Pfeiffer N, Grus FH (2021) Serological Levels of Anti-clathrin Antibodies Are Decreased in Patients With Pseudoexfoliation Glaucoma. Frontiers in immunology 12:616421.

    • Jiong Hu, Marco Sisignano, Roman Brecht, Natarajan Perumal, Carlo Angioni, Iris-Sofia Bibli, Beate Fisslthaler, Hartmut Kleinert, Norbert Pfeiffer, Ingrid Fleming and Caroline Manicam (2021). Cyp2c44 epoxygenase-derived epoxyeicosatrienoic acids in vascular smooth muscle cells elicit vasoconstriction of the murine ophthalmic artery. Scientific Reports 11, 18764.
    • David P. Herzog*, Natarajan Perumal*, Caroline Manicam, Giulia Treccani, Jens Nadig, Milena Rossmanith, Jan Engelmann, Tanja Jene, Annika Hasch, Michael A. van der Kooij, Klaus Lieb, Nils C. Gassen, Franz H. Grus and Marianne B. Müller (2021). Longitudinal CSF proteome profiling in mice to uncover the acute and sustained mechanisms of action of rapid acting antidepressant (2R,6R)-hydroxynorketamine (HNK). Neurobiology of Stress 15: 100404. *shared first authorship



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    • Grus, F.H., et al., Transthyretin and complex protein pattern in aqueous humor of patients with primary open-angle glaucoma. Mol Vis, 2008. 14: p. 1437-45.
    • Grus, F. and D. Sun, Immunological mechanisms in glaucoma. Semin Immunopathol, 2008. 30(2): p. 121-6.
    • Geerling, G., et al., [Legal regulations to produce serum eye drops : when is it necessary, and how can it be obtained?]. Ophthalmologe, 2008. 105(7): p. 632-8.
    • Brust, A.K., et al., Effects of Cyclooxygenase Inhibitors on Apoptotic Neuroretinal Cells. Biomark Insights, 2008. 3: p. 387-402.



    • Joachim, S.C., et al., IgG antibody patterns in aqueous humor of patients with primary open angle glaucoma and pseudoexfoliation glaucoma. Mol Vis, 2007. 13: p. 1573-9.
    • Joachim, S.C., et al., Analysis of IgG antibody patterns against retinal antigens and antibodies to alpha-crystallin, GFAP, and alpha-enolase in sera of patients with "wet" age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol, 2007. 245(5): p. 619-26.
    • Joachim, S.C., et al., Antibodies to alpha B-crystallin, vimentin, and heat shock protein 70 in aqueous humor of patients with normal tension glaucoma and IgG antibody patterns against retinal antigen in aqueous humor. Curr Eye Res, 2007. 32(6): p. 501-9.
    • Grus, F.H., S.C. Joachim, and N. Pfeiffer, Proteomics in ocular fluids. Proteomics Clin Appl, 2007. 1(8): p. 876-88.



    • Hoffmann, E.M., et al., [Goldmann applanation tonometry and dynamic contour tonometry. Comparison of intraocular pressure measurements in the course of product certification according to EN ISO 8612:2001]. Ophthalmologe, 2006. 103(4): p. 317-20.
    • Hoffmann, E.M., et al., Repeatability and reproducibility of optic nerve head topography using the retinal thickness analyzer. Graefes Arch Clin Exp Ophthalmol, 2006. 244(2): p. 192-8.
    • Hoffmann, E.M., et al., Glaucoma detection using the GDx nerve fiber analyzer and the retinal thickness analyzer (RTA). Eur J Ophthalmol, 2006. 16(2): p. 251-8.
    • Grus, F.H., et al., Serum autoantibodies to alpha-fodrin are present in glaucoma patients from Germany and the United States. Invest Ophthalmol Vis Sci, 2006. 47(3): p. 968-76.
    • Barleon, L., et al., Comparison of dynamic contour tonometry and goldmann applanation tonometry in glaucoma patients and healthy subjects. Am J Ophthalmol, 2006. 142(4): p. 583-90.



    • Joachim, S.C., N. Pfeiffer, and F.H. Grus, Autoantibodies in patients with glaucoma: a comparison of IgG serum antibodies against retinal, optic nerve, and optic nerve head antigens. Graefes Arch Clin Exp Ophthalmol, 2005. 243(8): p. 817-23.
    • Hoffmann, E.M., et al., [Laser in situ keratomileusis (LASIK) and scanning laser ophthalmoscopy]. Ophthalmologe, 2005. 102(9): p. 856-62.
    • Hoffmann, E.M., et al., Scanning laser polarimetry and retinal thickness analysis before and after laser in situ keratomileusis. Eur J Ophthalmol, 2005. 15(4): p. 434-40.
    • Hoffmann, E.M., et al., Agreement among 3 optical imaging methods for the assessment of optic disc topography. Ophthalmology, 2005. 112(12): p. 2149-56.
    • Hoffmann, E., et al., Scanning laser polarimetry and retinal thickness analysis before and after laser in situ keratomileusis. Eur J Ophthalmol, 2005. 15(4): p. 434-440.
    • Grus, F.H., et al., SELDI-TOF-MS ProteinChip array profiling of tears from patients with dry eye. Invest Ophthalmol Vis Sci, 2005. 46(3): p. 863-76.
    • Grus, F.H., et al., Effects of multipurpose contact lens solutions on the protein composition of the tear film. Cont Lens Anterior Eye, 2005. 28(3): p. 103-12.



    • Troost, A., et al., [Agreement between clinical evaluation, Heidelberg-Retina-Tomograph (HRT) and Nerve Fiber Analyzer (GDx) in glaucoma diagnosis]. Klin Monbl Augenheilkd, 2004. 221(9): p. 757-61.
    • Singer, H.S., et al., Anti-basal ganglia antibodies in PANDAS. Mov Disord, 2004. 19(4): p. 406-15.
    • Hoffmann, E.M., F.H. Grus, and N. Pfeiffer, Intraocular pressure and ocular pulse amplitude using dynamic contour tonometry and contact lens tonometry. BMC Ophthalmol, 2004. 4: p. 4.
    • Grus, F.H., et al., Complex autoantibody repertoires in patients with glaucoma. Mol Vis, 2004. 10: p. 132-7.



    • Singer, H.S., et al., Anti-basal ganglia antibody abnormalities in Sydenham chorea. J Neuroimmunol, 2003. 136(1-2): p. 154-61.
    • Joachim, S.C., F.H. Grus, and N. Pfeiffer, Analysis of autoantibody repertoires in sera of patients with glaucoma. Eur J Ophthalmol, 2003. 13(9-10): p. 752-8.
    • Grus, F.H., S.C. Joachim, and N. Pfeiffer, Analysis of complex autoantibody repertoires by surface-enhanced laser desorption/ionization-time of flight mass spectrometry. Proteomics, 2003. 3(6): p. 957-61.
    • Grus, F.H., et al., Immunological effects of allopurinol in the treatment of experimental autoimmune uveitis (EAU) after onset of the disease. Eur J Ophthalmol, 2003. 13(2): p. 185-91.
    • Fust, A., et al., Changes in tear protein pattern after photorefractive keratectomy. Eur J Ophthalmol, 2003. 13(6): p. 525-31.



    • Schwenn, O., et al., Ocular pulse amplitude in patients with open angle glaucoma, normal tension glaucoma, and ocular hypertension. Br J Ophthalmol, 2002. 86(9): p. 981-4.
    • Herber, S., et al., Changes in the tear protein patterns of diabetic patients using two-dimensional electrophoresis. Adv Exp Med Biol, 2002. 506(Pt A): p. 623-6.
    • Grus, F.H., et al., Analysis of tear protein patterns for the diagnosis of dry eye. Adv Exp Med Biol, 2002. 506(Pt B): p. 1213-6.
    • Grus, F.H., et al., Changes in the tear proteins of diabetic patients. BMC Ophthalmol, 2002. 2: p. 4.
    • Grus, F.H., et al., Effect of smoking on tear proteins. Graefes Arch Clin Exp Ophthalmol, 2002. 240(11): p. 889-92.



    • Wendlandt, J.T., et al., Striatal antibodies in children with Tourette's syndrome: multivariate discriminant analysis of IgG repertoires. J Neuroimmunol, 2001. 119(1): p. 106-13.
    • Vogel, A., et al., [Reproducibility of measurement of ocular pulse amplitude and intraocular pressure using Smartlens]. Ophthalmologe, 2001. 98(10): p. 944-9.
    • Troost, R., et al., Clinical comparison of two intraocular pressure measurement methods: SmartLens dynamic observing tonography versus Goldmann. Graefes Arch Clin Exp Ophthalmol, 2001. 239(12): p. 889-92.
    • Herber, S., et al., Two-dimensional analysis of tear protein patterns of diabetic patients. Electrophoresis, 2001. 22(9): p. 1838-44.
    • Grus, F.H., P. Sabuncuo, and A.J. Augustin, [Quantitative analysis of tear protein profile for soft contact lenses--a clinical study]. Klin Monbl Augenheilkd, 2001. 218(4): p. 239-42.
    • Grus, F.H., P. Sabuncuo, and A.J. Augustin, Analysis of tear protein patterns of dry-eye patients using fluorescent staining dyes and two-dimensional quantification algorithms. Electrophoresis, 2001. 22(9): p. 1845-50.
    • Grus, F.H., et al., Analysis of the antibody repertoire in tears of dry-eye patients. Ophthalmologica, 2001. 215(6): p. 430-4.
    • Grus, F.H., et al., [From the genome to the proteome]. Ophthalmologe, 2001. 98(12): p. 1132-7.
    • Grus, F.H., et al., Allopurinol has immunomodulating activity following topical and systemic application in experimental autoimmune uveitis. Eur J Ophthalmol, 2001. 11(3): p. 252-60.
    • Grus, F.H. and A.J. Augustin, High performance liquid chromatography analysis of tear protein patterns in diabetic and non-diabetic dry-eye patients. Eur J Ophthalmol, 2001. 11(1): p. 19-24.
    • Frohn, A., et al., Late opacification of the foldable hydrophilic acrylic lens SC60B-OUV. Ophthalmology, 2001. 108(11): p. 1999-2004.
    • Dziewas, R., et al., Antibody pattern analysis in the Guillain-Barre syndrome and pathologic controls. J Neuroimmunol, 2001. 119(2): p. 287-96.



    • Grus, F.H., et al., [Immunological effect of systemically administered allopurinol in experimental autoimmune uveitis]. Klin Monbl Augenheilkd, 2000. 216(3): p. 165-71.
    • Grus, F.H. and A.J. Augustin, [Protein analysis methods in diagnosis of sicca syndrome]. Ophthalmologe, 2000. 97(1): p. 54-61.



    • Grus, F.H. and A.J. Augustin, Analysis of tear protein patterns by a neural network as a diagnostical tool for the detection of dry eyes. Electrophoresis, 1999. 20(4-5): p. 875-80.
    • Augustin, A.J., et al., Effects of systemically applied allopurinol and prednisolone on experimental autoimmune uveitis. Graefes Arch Clin Exp Ophthalmol, 1999. 237(6): p. 508-12.



    • Grus, F.H. and H. Stieve, Kinetics of rhodopsin regeneration in situ and in the excised median eye of Limulus polyphemus measured using electrophysiological methods. Pflugers Arch, 1998. 435(6): p. 827-33.
    • Grus, F.H., A.J. Augustin, and K. Toth-Sagi, Diagnostic classification of autoantibody repertoires in endocrine ophthalmopathy using an artificial neural network. Ocul Immunol Inflamm, 1998. 6(1): p. 43-50.
    • Grus, F.H., et al., Analysis of tear-protein patterns as a diagnostic tool for the detection of dry eyes. Eur J Ophthalmol, 1998. 8(2): p. 90-7.
    • Grus, F.H. and A.J. Augustin, Analysis of the IgG autoantibody repertoire in endocrine ophthalmopathy using the MegaBlot technique. Curr Eye Res, 1998. 17(6): p. 636-41.
    • Augustin, A.J., et al., Effects of perfluorooctylbromide and vitamin E on ischemia induced retinal oxidative tissue damage. Exp Eye Res, 1998. 66(1): p. 19-24.
    • Armstrong, D., et al., Detection of vascular endothelial growth factor and tumor necrosis factor alpha in epiretinal membranes of proliferative diabetic retinopathy, proliferative vitreoretinopathy and macular pucker. Ophthalmologica, 1998. 212(6): p. 410-4.



    • Grus, F.H. and C.W. Zimmermann, Identification and classification of autoantibody repertoires (Western blots) with a pattern recognition algorithm by an artificial neural network. Electrophoresis, 1997. 18(7): p. 1120-5.
    • Grus, F.H., et al., Immunomodulating activity of allopurinol in experimental lens-induced uveitis. Graefes Arch Clin Exp Ophthalmol, 1997. 235(2): p. 118-23.
    • Grus, F.H., A.J. Augustin, and C.W. Zimmermann, Computer-supported analysis (MegaBlot) of allopurinol-induced changes in the autoantibody repertoires of rats suffering from experimental lens-induced uveitis. Electrophoresis, 1997. 18(3-4): p. 516-9.
    • Augustin, A.J., et al., Detection of eicosanoids in epiretinal membranes of patients suffering from proliferative vitreoretinal diseases. Br J Ophthalmol, 1997. 81(1): p. 58-60.



    • Koch, F.H., et al., Effects of different antioxidants on lens-induced uveitis. Ger J Ophthalmol, 1996. 5(4): p. 185-8.
    • Blumenroder, S., et al., Retino-choroidal oxygen imaging through a fundus camera. Adv Exp Med Biol, 1996. 388: p. 35-9.
    • Augustin, A.J., et al., Effects of allopurinol and steroids on inflammation and oxidative tissue damage in experimental lens induced uveitis: a biochemical and morphological study. Br J Ophthalmol, 1996. 80(5): p. 451-7.
    • Augustin, A.J., F.H. Grus, and S. Hunt, Effects of allopurinol on free-radical-induced reduction of the proliferation of retinal pigment epithelial cells. Doc Ophthalmol, 1996. 93(3): p. 231-6.



    • Zimmermann, C.W., F.H. Grus, and R. Dux, Multivariate statistical comparison of autoantibody-repertoires (western blots) by discriminant analysis. Electrophoresis, 1995. 16(6): p. 941-7.
    • Breipohl, W., et al., Effects of UV-B on the growth pattern of bovine passage I and II lens epithelial cells in vitro. Ophthalmic Res, 1995. 27 Suppl 1: p. 62-8.
    • Augustin, A.J., et al., Indicators of oxidative tissue damage and inflammatory activity in epiretinal membranes of proliferative diabetic retinopathy, proliferative vitreoretinopathy and macular pucker. Ger J Ophthalmol, 1995. 4(1): p. 47-51.
    • Augustin, A.J., et al., Oxidative reactions in the tear fluid of patients suffering from dry eyes. Graefes Arch Clin Exp Ophthalmol, 1995. 233(11): p. 694-8.